Table 1.

Treatment schema

Day 1		Day 1	2–8 weeks after EBRT	4–6 weeks after Brachy
LHRH* + Anti-androgen** →		EBRT∇ →	Cesium-131 Brachy# →	Adjuvant chemotherapy◄

^*LHRH (luteinizing hormone-releasing hormone) agonist (e.g., goserelin, leuprolide, etc) given for 24 months total starting Day#1 of EBRT (patients are eligible if LHRH was started within 60 days prior to EBRT).

^**Anti-androgen (e.g., flutamide, bicalutamide, etc) will be given for the first 28 days at the start of LHRH agonist (patients are eligible if anti-androgen was started within 90 days prior to EBRT).

^∇EBRT (External Beam Radiation Therapy) delivered at 1.8 Gy daily fractions, 5 days/week, for a total of 45 Gy to the pelvis. Bone marrow-sparing pelvic Intensity-Modulated Radiation Therapy (IMRT) technique is mandatory for the entire course of EBRT.

^#Brachy (Brachytherapy): Brachytherapy boost with Cesium-131 sources to a dose of 85 Gy.

^◄Adjuvant docetaxel will be administered at 75mg/m2 IV Q 21 days (plus or minus 2 to 3 days) for 4 cycles along with prednisone 10mg PO QD (from Day#1 of adjuvant docetaxel until 21 days after last docetaxel cycle infusion)