Table 2. Crude incidence and prevalence of MS in Hungary between 2010 and 2015.

	number of incident cases (women/men)	number of prevalent cases (women/ men)	woman/man ratio of prevalent cases	woman/man ratio of incident cases	total crude incidence (95% CI)	crude incidence among women (95% CI)	crude incidence among men (95% CI)	total crude prevalence (95% CI)	crude prevalence among women (95% CI)	crude prevalence among men (95% CI)
2010	703 (500/203)	10859 (7872/2987)	2.6	2.5	7.1 (6.6–7.6)	9.6 (8.8–10.5)	4.3 (3.7–4.9)	109.3 (107.2–111.4)	150.8 (147.5–154.2)	63.3 (61.1–65.6)
2011	616 (429/187)	11338 (8206/3132)	2.6	2.3	6.2 (5.7–6.7)	8.2 (7.5–9)	4.0 (3.4–4.6)	114.1 (112.0–116.2)	157.2 (153.9–160.7)	66.4 (64.1–68.7)
2012	653 (446/207)	11809 (8543/3266)	2.6	2.3	6.6 (6.1–7.1)	8.6 (7.8–9.4)	4.4 (3.8–5.0)	118.8 (116.7–121.0)	163.7 (160.2–167.2)	69.2 (66.9–71.6)
2013	625 (434/191)	12234 (8857/3377)	2.6	2.3	6.3 (5.8–6.8)	8.3 (7.6–9.1)	4.0 (3.5–4.7)	123.1 (120.9–125.3)	169.7 (166.2–173.3)	71.6 (69.2–74.0)
2014	592 (389/203)	12634 (9113/3521)	2.6	1.9	6.0 (5.5–6.5)	7.5 (6.7–8.2)	4.3 (3.7–4.9)	127.1 (124.9–129.4)	174.6 (171–178.2)	74.6 (72.2–77.1)
2015	538 (375/163)	12993 (9369/3624)	2.6	2.3	5.4 (5.0–5.9)	7.2 (6.5–8.0)	3.5 (2.9–4.0)	130.8 (128.5–133.0)	179.5 (175.9–183.2)	76.8 (74.3–79.4)
p-valuea	N.A.	N.A.	N.A.	N.A.	0.018276*	0.011609*	0.258283	0.000003*	0.000006*	0.000002*

Crude incidence: new patients/100,000 inhabitants/year. Crude prevalence: number of living patients/100,000 inhabitants.

^ap-value: p-value of trend significance test using linear regression. The p-value ≤0.05 was considered significant and is marked with asterisks*

N.A., not applicable; CI, confidence interval. Gamma confidence intervals were created using R version 3.6.2 with package “epitools”. The method is based on Daly [25].