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. 2020 Jul 27;15(7):e0236432. doi: 10.1371/journal.pone.0236432

Table 3. Age-adjusted standardized prevalence and incidence of MS in Hungary.

Age-adjusted standardized prevalence, total (95% CI) Age-adjusted standardized prevalence, women / men (95% CI) Age-adjusted standardized incidence, total (95% CI) Age-adjusted standardized incidence, women / men (95% CI)
2010 105.2 (103.2–107.3) 147.3 / 60.3 (144.0–150.6) / (58.1–62.5) 6.7 (6.2–7.2) 9.5 / 3.9 (8.7–10.4) / (3.4–4.4)
2011 109.9 (107.9–112.0) 153.3 / 63.4 (150.0–156.7) / (61.1–65.7) 5.9 (5.4–6.4) 8.1 / 3.7 (7.4–8.9) / (3.2–4.3)
2012 114.6 (112.5–116.7) 159.6 / 66.3 (156.2–163.0) / (64.0–68.7) 6.2 (5.7–6.7) 8.5 / 3.9 (7.7–9.3) / (3.4–4.5)
2013 119(116.9–121.2) 165.6 / 68.9 (162.2–169.1) / (66.5–71.3) 6 (5.5–6.5) 8.2 / 3.7 (7.5–9) / (3.2–4.3)
2014 123.4 (121.2–125.6) 170.7 / 72.2 (167.2–174.3) / (69.8–74.3) 5.7 (5.2–6.2) 7.4 / 3.9 (6.7–8.2) / (3.4–4.5)
2015 127.2 (125.0–129.4) 175.6 / 74.7 (172.0–179.2) / (72.2–77.2) 5.1 (4.7–5.6) 7.1 / 3.1 (6.4–7.9) / (2.7–3.7)
p-valuea 0.000001* 0.000002* / 0.000001* 0.015974* 0.012586* / 0.222197

Age standardization was performed using the 2013 European standard population. Incidence and prevalence are expressed as rate/100,000 population.

ap-value: p-value of trend significance test using linear regression. The p-value ≤0.05 was considered significant and is marked with asterisks*

CI, confidence interval. Gamma confidence intervals were created using R version 3.6.2 with package “asht”. The method is based on Fay & Feuer [26].