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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Med Chem Res. 2020 Jun 7;29(7):1199–1210. doi: 10.1007/s00044-020-02563-y

Table 1.

Average IC50 Values of analogs. (Experiment triplicates with 95% confidence intervals of IC50 showing in parentheses)

Compound NO. AQ ID Structure IC50 (μM)
1 AQ-101 graphic file with name nihms-1605688-t0008.jpg 1.37
(0.96-1.96)
3a AQ-270 graphic file with name nihms-1605688-t0009.jpg 2.06
(1.81-2.36)
3b AQ-271 graphic file with name nihms-1605688-t0010.jpg > 50
3c AQ-272 graphic file with name nihms-1605688-t0011.jpg > 50
6 AQ-285 graphic file with name nihms-1605688-t0012.jpg 2.27
(2.14-2.40)
9 AQ-273 graphic file with name nihms-1605688-t0013.jpg 3.12
(2.32-4.18)
12a AQ-332 graphic file with name nihms-1605688-t0014.jpg >50
12b AQ-333 graphic file with name nihms-1605688-t0015.jpg >50
13 AQ-131 graphic file with name nihms-1605688-t0016.jpg 0.74
(0.62-0.89)
17 AQ-283 graphic file with name nihms-1605688-t0017.jpg >50
18 AQ-284 graphic file with name nihms-1605688-t0018.jpg 1.75
(1.27-2.41)
19 AQ-317 graphic file with name nihms-1605688-t0019.jpg 17.6
(16.7-18.6)
20 AQ-340 graphic file with name nihms-1605688-t0020.jpg >50
22 AQ-282 graphic file with name nihms-1605688-t0021.jpg ≈50
25 AQ-300 graphic file with name nihms-1605688-t0022.jpg 25.9
(25.2-26.6)