Fig 1. Systematic experimental perturbation of cells leads to predictive network models.

We perturbed cells with combinations of targeted drugs and measured the time-resolved cellular response (step 1). These measurements were used as input to derive network models of the response to arbitrary combinatorial perturbations (step 2). Using these models, we identified drug combination targets that optimally reduce cell growth and increase apoptosis in a melanoma cell line (step 3).