Fig 4. Model-inferred effect of drugs on proteins and phospho-proteins.
The effect of drug treatment on (phospho-)protein levels is captured as edges between drugs (colored circles) and proteins (gray circles) in the model (represented by the drug–(phospo-)protein interaction strength dil from Eq 2). Some of the edges are well known (e.g., MEKi inhibits ERK1/2-pT202/T204) and some appear to be novel or indirect (e.g., inhibitory effect of PKCi on CREB-pS133). Based on the distribution of edge values over the 101 network models, only the strongest drug–protein edges are displayed for visualization purposes (85th percentile for positive/activating interactions and 15th percentile for negative/inhibiting interactions, by absolute value).