Table 2.

Univariate and multivariate analysis for predictors of positive biopsy result. Age, PSA, and Biopsy Cohort were predictive of a positive biopsy result.

Covariate	Univariate	P value	Holm*	Multivariate**	P value	Holm*
Patient age (years)	0.98	<0.001	0.002	0.68	0.001	0.002
PSA (ng/mL)	0.59	<0.001	0.002	0.77	<0.001	0.002
Prostate Volume (cc)**	−1.22	<0.001	0.002	−2.04	<0.001	0.002
PSA Density (ng/mL/cc)**	0.004	<0.001	0.002	−0.0008	0.67	0.008
Year of biopsy	0.11	0.014	0.003	0.02	0.85	0.013
Number of cores taken	−0.33	0.27	0.007	0.58	0.26	0.005
Biopsy cohort***	−0.08	0.004	0.002	−0.14	0.03	0.003
Race
Caucasian	0.05	0.04	0.003	0.19	0.04	0.003
Asian	−0.24	0.05	0.004	0.007	0.94	0.025
African American	0.15	0.01	0.003	0.24	0.03	0.003
Hispanic	−0.09	0.35	0.008	0.08	0.51	0.006
Other or Unknown	−0.06	0.03	0.003	0.08	0.44	0.006
Diagnosing physician****
1 (N=115)	0.05	0.13	0.005	0.18	0.004	0.003
2 (N=18)	−0.18	0.01	0.003	−0.12	0.65	0.007
3 (N=7)	0.06	.65	0.050	−0.01	0.94	0.050
4 (N=69)	−0.06	0.18	0.006	0	0.14	0.004
5 (N=1)	−0.44	0.38	0.010	0	0.002	0.002
6 (N=88)	0.06	0.16	0.005	0.61	0.07	0.004
7 (N=2)	0.56	0.26	0.006	0	0.04	0.003
8 (N=102)	−0.15	0.42	0.013	0.04	0.84	0.010
9 (N=3)	−0.07	0.09	0.004	0	0.04	0.004
10 (N=7)	−0.22	0.09	0.004	0.04	0.91	0.017
11 (N=3)	−0.08	0.55	0.025	0	<0.001	0.002
12 (N=10)	0.23	0.42	0.017	0.55	0.23	0.005
13 (N=533)	−0.28	0.04	0.003	−0.35	0.03	0.003

^*Represents statistical significance threshold of alpha = 0.05 with Holm stepdown correction.

^**Analysis performed with the 820 patients with prostate volume data available.

^***Categorical variable represented as FHB – 1, TMB – 0.

^****Physician 8 performed all TMB and no FHB.