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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Lancet. 2015 Nov 3;387(10028):1657–1671. doi: 10.1016/S0140-6736(15)00728-X

Figure 4: Proteins involved in mineralisation of the collagen extracellular matrix.

Figure 4:

The transmembrane protein-bone restricted interferon induced transmembrane protein-like—regulates the expression of pigment epithelium derived factor, an important collagen-binding protein regulating bone homoeostasis and osteoid mineralisation, which also has strong anti-angiogenic functions by an unknown mechanism. SERPINF1 is the gene for pigment epithelium derived factor. The question marks refer to the presence of other factors in this pathway, which are not yet discovered. The plus and minus signs refer to increased and decreased transcription of the SERPINF1 gene. S40L refers to the IFITM5 mutation Ser40Leu.