Table 7. Comparison of risk of HCC development after cirrhosis diagnosis, according to cause of cirrhosis.
| Variables | No. of cirrhosis patients | No. with HCC among cirrhosis patients | HRa | P value | |
|---|---|---|---|---|---|
| 2000–2012 | |||||
| HBV | 6,879 | 2,545 | 1 | ||
| HCV | 1,027 | 385 | 0.74 (0.62–0.88) | 0.001 | |
| Alcohol | 4,582 | 784 | 0.34 (0.30–0.39) | < 0.001 | |
| NAFLD | 464 | 98 | 0.49 (0.34–0.72) | < 0.001 | |
| 2000–2003 | |||||
| HBV | 2,375 | 750 | 1 | ||
| HCV | 260 | 88 | 1.01 (0.61–1.67) | 0.963 | |
| Alcohol | 1,398 | 194 | 0.56 (0.40–0.78) | < 0.001 | |
| NAFLD | 78 | 14 | 0.40 (0.19–0.85) | 0.017 | |
| 2004–2008 | |||||
| HBV | 2,551 | 895 | 1 | ||
| HCV | 400 | 134 | 0.66 (0.48–0.90) | 0.009 | |
| Alcohol | 1,761 | 276 | 0.41 (0.33–0.51) | < 0.001 | |
| NAFLD | 157 | 39 | 0.56 (0.25–1.26) | 0.162 | |
| 2009–2012 | |||||
| HBV | 1,953 | 900 | 1 | ||
| HCV | 367 | 163 | 0.78 (0.61–1.03) | 0.076 | |
| Alcohol | 1,423 | 314 | 0.30 (0.24–0.37) | < 0.001 | |
| NAFLD | 229 | 45 | 0.38 (0.21–0.69) | < 0.001 | |
HCC = hepatocellular carcinoma, HR = hazard ratio, HBV = hepatitis B virus, HCV = hepatitis C virus, NAFLD = non-alcoholic fatty liver disease.
aAdjusted by Cox proportional hazards analysis for age, sex, etiologies of cirrhosis, decompensated cirrhosis (defined as the presence of ascites, hepatic encephalopathy, gastroesophageal varices or hepatorenal syndrome), hemoglobin, platelet count, bilirubin, albumin, and alanine aminotransferase.