Table 1. Parameter values of the control and mutation condition.
Variables | Control | N588K | L532P | |
---|---|---|---|---|
gKr | ||||
P1, nS/pF | 0.029412 | 0.029412 | 0.09172 | |
Inactivation | ||||
P2, mV | 15 | −38.65 | −15.54 | |
P3, mV | 22.4 | 19.46 | 24.37 | |
Activation | ||||
P4, mV | 14.1 | 16.49 | −9.88 | |
P5, mV | 6.5 | 6.76 | 22.31 | |
A | ||||
P6, 1/mVmsec | 0.0003 | 0.0003 | 0.00025 | |
P7, mV | 14.1 | 14.1 | −196.86 | |
P8, mV | −5 | −5 | −131.36 | |
B | ||||
P9, mV | −3.3328 | −3.3328 | −40 | |
P10, mV | 5.1237 | 5.1237 | 3.79 × 10−6 | |
KQ10 | ||||
P11, 1 | 1 | 2 | 1 |
The parameters were obtained based on the experimental data from the work of Loewe et al.22