Table 3. Comparison of action potential and IKr current results between the original and modified crn cell models (WT, N588K, L532P).
| Variables | Original CRN cell model | Modified CRN cell model | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Action potential | IKr current | Action potential | IKr current | |||||||
| Amplitude | APD90 | APD50 | IKr,max | t(IKr,max) | Amplitude | APD90 | APD50 | IKr,max | t(IKr,max) | |
| WT | 100.41 | 308.0 | 184.9 | 0.298 | 179.2 | 95.49 | 214.4 | 160.6 | 1.003 | 163.4 |
| N588K | 101.75 | 236.4 | 116.5 | 0.593 | 95.0 | 104.99 | 135.9 | 76.8 | 1.703 | 63.6 |
| L532P | 102.95 | 160.5 | 71.1 | 0.880 | 66.0 | 105.26 | 111.8 | 63.2 | 2.125 | 60.0 |
APD = action potential duration, CRN = Courtemanche-Ramirez-Nattel, IKr = rapid delayed rectifier potassium channel, t = time, WT = wildtype.