Table III:
Estimated mean difference in cognitive test scores (and 95% confidence intervals).
| Model 1a | Model 2a | Model 3a, b | |||
|---|---|---|---|---|---|
| Higher-risk vs. Lower-risk | Treated vs. Treatment Naïve | Higher-risk vs. Lower-risk | Treated vs. Treatment Naïve | ||
| Direction Of Better Score | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | |
| NIH-TB Total Composite Scorec (primary outcome) | Higher | −1.96 (−4.94,1.01) | −0.38 (−3.53,2.77) | −1.96 (−4.99,1.07) | −0.03 (−3.22,3.16) |
| Dimensional Change Card Sort | Higher | −2.05 (−5.34,1.23) | −0.58 (−4.06,2.90) | −2.01 (−5.36,1.33) | −0.22 (−3.74,3.31) |
| Oral Reading Recognition | Higher | −3.22 (−6.78,0.34)* | 0.82 (−2.97,4.61) | −3.45 (−7.08,0.17)* | 1.44 (−2.37,5.26) |
| Picture Vocabulary Test | Higher | −2.20 (−4.76,0.36)* | −0.41 (−3.13,2.31) | −2.19 (−4.80,0.41)* | −0.01 (−2.76,2.73) |
| Flanker Inhibitory Control & Attention | Higher | −0.17 (−2.46,2.13) | −0.81 (−3.23,1.61) | −0.04 (−2.37,2.30) | −0.80 (−3.26,1.66) |
| List Sorting Working Memory | Higher | 0.41 (−2.46,3.27) | −0.48 (−3.50,2.54) | 0.50 (−2.42,3.42) | −0.57 (−3.64,2.50) |
| Pattern Comparison | Higher | 0.35 (−3.49,4.19) | −0.80 (−4.84,3.24) | 0.50 (−3.41,4.41) | −0.89 (−5.01,3.23) |
| Picture Sequence Matching | Higher | 0.66 (−2.68,4.01) | −0.69 (−4.21,2.83) | 0.80 (−2.61,4.20) | −0.83 (−4.42,2.75) |
| HVLT-R Total Correct Immediate Recall | Higher | -1.81 (−3.29,−0.32)e | −0.44 (−2.04,1.15) | -1.79 (−3.30,−0.28)e | −0.14 (−1.73,1.45) |
| HVLT-R Total Correct Delayed Recall | Higher | −0.38 (−1.19,0.44) | −0.10 (−0.96,0.76) | −0.37 (−1.20,0.46) | −0.04 (−0.91,0.84) |
| TMT-A time in secondsd | Lower | 6.89 (0.24,13.54)e | 3.46 (−3.59,10.51) | 6.54 (−0.20,13.28)* | 2.43 (−4.63,9.50) |
| TMT-B time in secondsd | Lower | 15.41 (3.32,27.51)e | 2.69 (−10.26,15.65) | 15.37 (3.10,27.65)e | 0.28 (−12.59,13.15) |
| COWA total correct words | Higher | 0.21 (−0.96,1.38) | 0.66 (−0.57,1.89) | 0.11 (−1.07,1.30) | 0.64 (−0.61,1.89) |
| FACT-Cog | Higher | −0.08 (−3.96,3.80) | -6.12 (−10.07,−2.17)f | 0.84 (−2.98,4.66) | -6.26 (−10.27,2.25)f |
NIH-TB: National Institutes of Health Toolbox Cognition Battery; FACT-Cog: Functional Assessment After Cancer Treatment Cognition; COWA: Controlled Word Association Test; HVLT-R: Hopkins Verbal Learning Test Revised; TMT-A/B: Trail Making Test A or B.
Boldindicates statistical significance p<0.05,
indicates p<0.10, prior to adjustment for multiple comparisons. False discovery rate adjusted p-values are available in Supplemental Table 1.
Model adjusted for age, gender, race, and education,
model mutually assessed both treatment and risk status,
fully adjusted NIH toolbox scores are t –scores,
these models had three potential influential outliers, estimates upon removal: TMT-A Model 1 β =4.16 95%CI −0.21 to 8.52; TMT-B Model 1 β =11.63 95%CI 2.82 to 20.45; TMT-A Model 3 β =4.07 95%CI −0.37 to 8.52; TMT-B Model 3 β =13.20 95%CI 1.70 to 24.69,
after adjustment for multiple comparisons trends remained (P<0.2) but were no longer significant,
after adjustment for multiple comparisons effect remains significant (p=0.030).