Table 1:

Summary of data acquired in the sensorimotor and anterior cingulate cortices, including number of datasets included, average linewidth, mean and standard deviation of the quantified Glx and Glu concentrations, and fit metrics (CRLB) for each metabolite.

		PRESS-35	OFF-GABA+	OFF-MM-Sup	DIFF-GABA+	DIFF-MM-Sup
SM	n	15	15	15	15	15
	FWHM (Hz)	4.2 ± 0.9	4.5 ± 0.9	4.0 ± 0.6	5.5 ± 1.8	3.8 ± 1.0
	Glx
	Mean ± SD (mol/kg)	13.1 ± 1.5	13.8 ± 1.2	9.6 ± 1.0	6.1 ± 0.5	2.8 ± 0.4
	%CRLB Range	5–8	6–9	6–10	2–4	3–7
	CoV	0.12	0.10	0.10	0.08	0.15
	Glu
	Mean ± SD (mol/kg)	10.9 ± 1.3	12.8 ± 1.1	9.1 ± 0.9	5.0 ± 0.5	2.5 ± 0.4
	%CRLB Range	5–7	6–9	6–9	4–7	4–15
	CoV	0.12	0.08	0.09	0.11	0.14
ACC	n	12	12	10	11	9
	FWHM (Hz)	6.1 ± 0.9	5.5 ± 1.3	6.0 ± 1.4	6.4 ± 1.3	6.5 ± 1.4
	Glx
	Mean ± SD (mol/kg)	18.8 ± 2.3	15.6 ± 3.0	12.8 ± 2.2	7.4 ± 0.7	2.9 ± 0.5
	%CRLB Range	4–7	6–12	6–11	3–4	4–6
	CV	0.12	0.19	0.18	0.09	0.19
	Glu
	Mean ± SD (mol/kg)	15.5 ± 2.0	13.8 ± 3.0	11.8 ± 1.7	5.3 ± 0.8	2.6 ± 0.5
	%CRLB Range	4–6	6–12	6–11	4–10	4–9
	CoV	0.13	0.21	0.14	0.16	0.20

Mean ± standard deviation, FWHM = full width half maximum estimated by LCModel, CRLB = Cramér-Rao lower bounds as calculated by LCModel, CoV = coefficient of variation, SM = Sensorimotor Cortex, ACC = Anterior Cingulate Cortex, Glx = Glutamate+Glutamine, Glu = Glutamate, GABA+ =GABA plus macromolecules (TE=68 ms), MMSup=macromolecule suppressed (TE=80 ms), OFF=data quantified from the OFF sub-spectra, DIFF=data quantified from the difference spectra.