Table 4.

Teriflunomide plasma pharmacokinetic summary

Patient #	Dose (mg/day)	*Cmaxtotal (µM)	Cmaxfree (µM)	^AUCtotal (µM x day)	AUCfree (µM x day)	AUCfree/AUCtotal (%)
1	20	138.3	0.29	2110.5	4.0	0.19
2	20	127.9	0.24	1839.0	3.3	0.18
3	20	212.8	0.27	2644.7	3.0	0.11
4	40	309.0	0.68	3325.7	5.8	0.17
5	40	334.0	0.73	3085.7	5.2	0.17
6	40	533.9	1.79	4501.2	10.6	0.23
7	60	523.0	0.83	8689.3	13.7	0.16
8	60	475.7	1.79	6660.2	25.1	0.38
9	60	695.2	2.75	3232.2	5.7	0.17
10	60	190.7	0.39	8728.9	11.3	0.13
11	60	673.4	0.95	4775.8	7.0	0.15
12	60	339.0	0.57	2798.3	4.9	0.17

^*Cmax = maximum plasma concentrations

^{^}Area under the concentration-time curve from Cycle 1, Day 1 to Cycle 2, Day 1