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. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: Cell. 2020 Jul 2;182(2):297–316.e27. doi: 10.1016/j.cell.2020.05.049

Figure 4. Tbl1xr1 mutations bias cell fate towards MB.

Figure 4.

A-B, GSEA of antigen-specific (A) MB or (B) PC, relative to GCB (GSE4142), against D370Y/WT GCB.

C, Experimental scheme and timeline for D-G.

D-E, FC analysis of (D) total YFP+ splenocytes in IgG(Ctrl Ab) treated mice, and (E) the relative cell type composition of this population. Results for 4 animals. See also Figure S4C and Data S1U.

F-G, FC analysis of (F) total YFP+ splenocytes in anti-CD40L treated mice, and (G) the relative cell type composition of this population. Results for 4 animals.

H, FC analysis of cell type composition of antigen-specific splenocytes. Results for 5 animals. See also Data S1V.

I, FC analysis of (top) total or (bottom) GC-derived BM LLPC.

Values represent mean ± SEM. Data reproducible with two repeats. P-values calculated using unpaired (H,I) or paired (D-G) two-tailed Student’s t-test.