. 2020 Apr 22;35(9):1749–1759. doi: 10.1007/s00467-020-04560-0

Table 4.

Comparison of clinical and microbiological findings in patients on temporary dialysis (n = 55) with those not needing kidney replacement therapy (n = 32) as well as in patients with (n = 29) and without (n = 58) major CNS symptoms using binary logistic regression model

Number	Short-term kidney function			Major CNS symptoms
Number	Dialysis (55)	No dialysis (32)	OR (95% CI), p value	CNS (29)	No CNS (58)	OR (95% CI), p value
Age < 3 years	25 (45%)	16 (52%)	0.83 (0.35–2.00), NS	16 (55%)	25 (43%)	1.63 (0.66–3.99), NS
Antimicrobial treatment, all	40 (74%)^a	7 (22%)	10.20 (3.62–28.75), < 0.001	22 (76%)	25 (44%)^a	10.20 (3.62–28.75), < 0.001
Antimicrobial treatment, started before dialysis^c	9 (17%)^a	7 (22%)	0.71 (0.24–2.15), NS	3 (10%)	25 (44%)^a	0.15 (0.04–0.54), 0.004
Leukocytes > 20 E9/L	30 (57%)^b	9 (29%)^a	3.19 (1.24–8.22), 0.02	18 (64)^a	21 (38%)^b	3.19 (1.24–8.22), 0.02
Hemoglobin > 9.5 g/dL	33 (62%)	12 (38%)	2.75 (1.11–6.80), 0.03	19 (66%)	26 (46%)^b	2.19 (0.87–5.55), NS
Presence of anuria	43 (80%)^a	1 (3%)	121.18 (14.86–988.16), < 0.001	20 (69%)	24 (42%)^a	3.06 (1.19–7.88), 0.02
O157^d	26 (74%)	11(52%)	2.62 (0.84–8.24), NS	15 (79%)	22 (59%)	2.56 (0.71–9.23), NS
Stx1 alone^d	2 (6%)	0 (0%)		1 (5%)	1 (3%)	2.00 (0.12–33.86), NS
Stx2 alone^d	31 (89%)	20 (95%)	0.39 (0.04–3.72), NS	17 (89%)	34 (92%)	0.75 (0.11–4.92), NS
Stx1 and Stx2^d	2 (6%)	1 (5%)	1.21 (0.10–14.24), NS	1 (5%)	2 (5%)	0.97 (0.08–11.46), NS

OR odds ratio, CI confidence interval, NS nonspecific, CNS central nervous system

^aData missing from one patient

^bData missing from two patients

^cData analyzed taking into account only those cases, in whom the antimicrobial treatment was started before dialysis in the dialysis group

^dIncludes 56 patients [(1) renal short-term outcome analysis: 35 with dialysis and 21 without and (2) major CNS symptoms; 19 with CNS symptoms and 37 without], on whom whole genome sequencing data were available