Fig. 7.

EI sequence alignment. The sequence of the E. coli EI is aligned against EI from other, randomly selected, drug-resistant bacteria: Citrobacter freundii (identity 97%; similarity 99%; gaps 0%), Klebsiella pneumoniae (identity 96%; Similarity 98%; gaps 0%), Staphylococcus aureus (identity 51%; similarity 70%; gaps 0%), Enterococcus faecalis (identity 49%; similarity 68%; gaps 1%), and Neisseria gonorrhorae (identity 36%; similarity 58%; gaps 2%). Residues forming the allosteric pocket are in red. Blue and red lines indicate the EIN and EIC domains, respectively. Dashed lines indicate the locations of ⍺-helices 1 and 2 and β-strand 1. Full sequence alignments are shown in Supplementary Fig. S1. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)