Table 2.
Significantly (p < 0.0005) differentially expressed genes reported in literature as regulators of neural development.
| Gene | Description | Function | References |
|---|---|---|---|
| Npdc1 | Neural proliferation, differentiation and control 1 | Responsible for regulating differentiation. Upregulated in adult brains compared to young brains | Qu, X. et al.38, Evrard, C. et al.39, Galiana, E. et al.40, Sansal, I. et al.41 |
| Crabp2 | Cellular retinoic acid binding protein II | Upregulated in differentiated Motor Neurons, and downregulated in mature motor neurons | Boucherie, C. et al., Chaerkady, R. et al., Zhang, Q. et al |
| Snap47 | Synaptosomal-associated protein, 47 | Involved in unique fusion machinery for postsynaptic and presynaptic function | Münster-Wandowski, A. et al. Holt, M. et al. Arora, S. et al |
| Tubgcp4 | Tubulin, gamma complex associated protein 4 | Important in the nucleation and polar orientation of microtubules | Scheidecker, S. et al. Sánchez-Huertas, C. et al |
| Aplp1 | Amyloid beta (A4) precursor-like protein 1 | Supports maintenance of dendritic spines and basal synaptic transmission. High impact on synapse formation and synaptic plasticity. Is upregulated during synaptogenesis and is essential for proper synapse formation | Mayer, M. C. et al.42, Schilling, S. et al.43, Weyer, S. W. et al.44, Klevanski, M. et al.45, Kim, T.-W. et al.46 |
| Cacng7 | Calcium channel, voltag E-dependent, gamma subunit 7 | Critical to Neural communication for Ca-dependent fusion of two secretory organelles: synaptic vesicles (SV) and neuropeptide-filled dense-core vesicles (DCV). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs) | Yang, L. et al., Kato, A. S. et al |
| Cnih2 | Cornichon family AMPA receptor auxiliary protein 2 | Influences the efficacy of excitatory synaptic transmission. Slows synaptic transmission for reliable and successful transmission of a sugnal accros the synapse | Boudkkazi, S. et al., Boudkkazi, S. et al., Shi, Y. et al. Gu, X. et al |
| Insyn1 | Inhibitory synaptic factor 1 | Regulates postsynaptic inhibition and contributes to brain development | Gamlin, C. R. et al., Uezu, A. et al |
| Vamp2 | Vesicle-associated membrane protein 2 | Involved in the dockin and/or fusion of synaptic vesicles with the presynaptic membrane. It forms a distinct complex with synaptophysin | Russell, C. L. et al. Schwarz, T. L. Winkle, C. C. & Gupton, S. L. Winkle, C. C. & Gupton, S. L. Koo, S. J. et al |
| Reep2 | Receptor accessory protein 2 | Expressed in neuronal exocytotic tissue | Sjöstedt, E. et al. Esteves, T. et al. Hübner, C. A. & Kurth, I. Hurt, C. M. et al |
| Ngfr | Nerve growth factor receptor (TNFR superfamily, member 16) | Receptor for member of signaling pathway activating neurothrophins, p75NTR | Huang, E. J. & Reichardt, L. F. Barrett, G. L. & Bartlett, P. F |
| Nptx1 | Neuronal pentraxin 1 | Key factor in synapse loss and neurite damage | Omeis, I. A. et al., Abad, M. A. et al., Dodds, D. C. et al., |
| Tuba1a | Tubulin, alpha 1A [ | Key factor in axon and dendritic growth and network development | Belvindrah, R. et al. Aiken, J. et al |