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. 2020 Jul 27;10:12504. doi: 10.1038/s41598-020-68892-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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3D super-resolution imaging of metaphase chromosomes. (a) Three-dimensional BALM images of an undamaged human metaphase chromosome. (b) 3D BALM images of an irradiated chromosome. A schematic representation of irradiated chromosome with a groove on one of the arms and three-dimensional surface plots at the upper (blue), and lower (red), layers. (c) (Top left) Wide-field image of a SxO-stained human chromosome (blue) and telomeric regions on the chromosome (magenta). (Bottom left) A top view of merged re-constituted super resolution (BALM) image of the chromosome and re-constituted super resolution (STORM) image of the telomeric regions of this chromosome. (Right) Three-dimensional surface plots of BALM (blue), STORM (red), and both images superimposed.