Fig. 2. PGD expression is frequently upregulated in resistant cells and tissues in GIST.
a qRT-PCR analysis of the expression of key enzymes in glycometabolism pathway in sensitive and resistant cell lines. b PGD expression level in sensitive and resistant tissues of GIST analyzed by qRT-PCR. c G6PD expression level in sensitive and resistant tissues of GIST analyzed by qRT-PCR. d Dot plot demonstrating the correlation between the IM intracellular concentration and G6PD and PGD expression level in GIST cells with various resistant capacity analyzed by qRT-PCR. e Levels of PGD and G6PD protein in GIST cells. f Levels of PGD and G6PD protein in GIST tissues. The error bars represent the mean (n = 3) ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001.