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. 2020 Jul 27;10:12497. doi: 10.1038/s41598-020-69236-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of age, LPS, or bleomycin on mRNA levels of SIRT7 and pro-inflammatory and pro-fibrotic markers measured by RT-qPCR in mouse lung tissues. ICAM1, VCAM1, IL6, and SIRT7 mRNA levels normalized to respective β-actin mRNA levels in lung tissue samples of C57BL/6 (A) or A/J mice (B) 24 h after intranasal treatment with LPS or PBS. (C) ICAM1, VCAM1, SIRT7, COL1A1, COL1A2, and COL3A1 mRNA levels normalized to respective 18S rRNA levels in lung tissue samples of C57BL/6 mice 14 days after intra-tracheal instillation of bleomycin or PBS. (D) SIRT7 mRNA levels relative to GAPDH in 5 week- and 18 month-old C57BL/6 mice. Data are expressed as fold changes relative to average mRNA levels in control (PBS-treated) mice in (A–C) and fold changes relative to average mRNA value in 5 week-old mice in (D). Each circle represents a separate tested animal. ○ Control (PBS-treated mice), ● LPS- or bleomycin-challenged mice. Means and standard deviations are shown. P values were calculated using the Mann–Whitney U-test.