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. 2020 Jul 27;10:12497. doi: 10.1038/s41598-020-69236-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of SIRT7 silencing on EndoMT in primary pulmonary endothelial cells. (A) WB for SIRT7, VE-Cadherin, PECAM1, α-SMA, and Snail in CTRL- or SIRT7-silenced HPAEC. Densitometry values (RDU) for VE-Cadherin relative to GAPDH (shown in Supplementary Figure 8C), PECAM1 relative to relative to α-tubulin, and α-SMA and Snail relative to GAPDH (Supplementary Figure 8H) are shown in each panel. (B) Representative IF images for VE-Cadherin and PECAM1 in CTRL- or SIRT7-silenced HPAEC. Bars represent average pixel intensities and brackets standard deviations of 6 images per condition. (C) WB for SIRT7 and PECAM1 in CTRL- or SIRT7-silenced HPMVEC. Densitometry values for PECAM1 relative to α-tubulin (RDU) are shown. (D) IF for VE-Cadherin and PECAM1 in CTRL- or SIRT7-silenced HPMVEC. Bars represent average pixel intensities and brackets standard deviations of 6 images per condition. Significant differences (P < 0.05) are denoted by stars. P values were calculated using the Student’s t-test. In (A,C), different proteins for the same group of samples are demarcated by white spaces.