Table 2.
Subgroup analysis for serum and plasma levels of inteleukin-6 in adults.
| Subgroup analysis of serum level (n) | MD (95% CI), P-value, I2 (%), Ph | Subgroup analysis of plasma level (n) | MD (95% CI), P-value, I2 (%), Ph |
|---|---|---|---|
| Overall (37) | 2.89 (2.54, 3.24), <0.00001, 99, <0.00001 | Overall (20) | 2.89 (1.94, 3.85), <0.00001, 99, <0.00001 |
| Ethnicity | Ethnicity | ||
| Caucasian (16) | 0.51 (0.29, 0.73), <0.00001, 97, <0.00001 | Caucasian (10) | 0.75 (−0.06, 1.57), 0.07, 98,<0.00001 |
| Asian (14) | 11.52 (10.20, 12.83), <0.00001, 100, <0.00001 | Asian (6) | 8.93 (4.87, 12.99), <0.0001, 100, <0.00001 |
| Mixed (7) | 2.49 (0.80, 4.17), 0.004, 96, <0.00001 | Mixed (4) | 0.75 (0.21, 1.29), 0.006, 45, 0.14 |
| Mean BMI of OSAS patients, kg/m2 | Mean BMI of OSAS patients, kg/m2 | ||
| >30 (15) | 1.07 (0.63, 1.50), <0.00001, 97, <0.00001 | >30 (8) | 0.96 (−1.16, 3.07), 0.38, 98, <0.00001 |
| ≤ 30 (19) | 10.59 (8.64, 12.53), <0.00001, 100, <0.00001 | ≤ 30 (11) | 4.20 (2.95, 5.46), <0.00001, 99, <0.00001 |
| Mean BMI of controls, kg/m2 | Mean BMI of controls, kg/m2 | ||
| >30 (12) | 0.47 (0.19, 0.76), 0.001, 89, <0.00001 | >30 (4) | 1.69 (−4.61, 8.00), 0.60, 99, <0.00001 |
| ≤ 30 (22) | 9.55 (7.85, 11.25), <0.00001, 100, <0.00001 | ≤ 30 (15) | 3.05 (2.096, 4.01), <0.00001, 99, <0.00001 |
| Total number of participants | Total number of participants | ||
| >100 (9) | 9.52 (2.94, 16.11), 0.005, 100, <0.00001 | >100 (5) | 0.42 (0.00, 0.84), 0.05, 92, <0.00001 |
| ≤ 100 (28) | 1.43 (1.14, 1.71), <0.00001, 99, <0.00001 | ≤ 100 (15) | 4.56 (2.51, 6.61), <0.0001, 99, <0.00001 |
| Mean AHI of OSAS patients, events/h | Mean AHI of OSAS patients, events/h | ||
| >30 (14) | 6.13 (5.31, 6.95), <0.00001, 100, <0.00001 | >30 (9) | 5.87 (3.37, 8.37), <0.00001, 99, <0.00001 |
| ≤ 30 (10) | 1.93 (1.20, 2.66), <0.00001, 98, <0.000101 | ≤ 30 (7) | 0.43 (0.10, 0.75), 0.01, 82, <0.00001 |
BMI, body mass index; CI, confidence interval; OSAS, obstructive sleep apnea syndrome; MD, mean difference; Ph, Pheterogeneity.
Bold numbers show statistically significant value (P < 0.05).