Table 3.
Subgroup analysis for serum and plasma levels of inteleukin-6 in adult Caucasians.
| Subgroup analysis of serum level (n) | MD (95% CI), P-value, I2 (%), Ph | Subgroup analysis of plasma level (n) | MD (95% CI), P-value, I2 (%), Ph |
|---|---|---|---|
| Overall (16) | 0.51 (0.29, 0.73), <0.00001, 97, <0.00001 | Overall (10) | 0.75 (−0.06, 1.57), 0.07, 98, <0.00001 |
| Mean BMI of OSAS patients, kg/m2 | Mean BMI of OSAS patients, kg/m2 | ||
| >30 (11) | 0.35 (0.09, 0.62), 0.008, 87, <0.00001 | >30 (5) | 0.46 (0.01, 0.91), 0.05, 92, <0.00001 |
| ≤ 30 (3) | 2.54 (0.90, 4.19), 0.002, 92, <0.00001 | ≤ 30 (5) | 0.89 (0.27, 1.50), 0.005, 96, <0.00001 |
| Mean BMI of controls, kg/m2 | Mean BMI of controls, kg/m2 | ||
| >30 (11) | 0.35 (0.09, 0.62), 0.008, 87, <0.00001 | >30 (3) | 2.26 (−5.67, 10.20), 0.58, 99, <0.00001 |
| ≤ 30 (3) | 2.54 (0.90, 4.19), 0.002, 92, <0.00001 | ≤ 30 (7) | 0.71 (0.19, 1.23), 0.007, 95, <0.00001 |
| Total number of participants | Total number of participants | ||
| >100 (3) | 1.81 (0.75, 2.87), 0.0008, 78, 0.01 | >100 (4) | 0.56 (−0.28, 1.41), 0.19, 93, <0.00001 |
| ≤ 100 (13) | 0.34 (0.11, 0.56), 0.003, 97, <0.00001 | ≤ 100 (6) | 1.14 (−1.72, 4.00), 0.44, 99, <0.00001 |
| Mean AHI of OSAS patients, events/h | Mean AHI of OSAS patients, events/h | ||
| >30 (6) | 0.23 (−0.11, 0.57), 0.18, 77, 0.0006 | >30 (5) | 1.48 (1.26, 1.70), <0.00001, 26, 0.25 |
| ≤ 30 (6) | 0.61 (0.33, 0.88), <0.0001, 88, <0.0001 | ≤ 30 (4) | 0.19 (0.16, 0.23), <0.00001, 24, 0.27 |
BMI, body mass index; CI, confidence interval; OSAS, obstructive sleep apnea syndrome; MD, mean difference; Ph, Pheterogeneity.
Bold numbers show statistically significant value (P < 0.05).