Table 5.
Subgroup analysis for serum and plasma levels of inteleukin-6 in adults where mean BMI of OSAS patients >30 kg/m2.
| Subgroup analysis of serum level (n) | MD (95% CI), P-value, I2 (%), Ph | Subgroup analysis of plasma level (n) | MD (95% CI), P-value, I2 (%), Ph |
|---|---|---|---|
| Overall (15) | 1.07 (0.63, 1.50), <0.00001, 97, <0.00001 | Overall (8) | 0.96 (−1.16, 3.07), 0.38, 98, <0.00001 |
| Mean BMI of controls, kg/m2 | Mean BMI of controls, kg/m2 | ||
| >30 (11) | 0.35 (0.09, 0.62), 0.008, 87, <0.00001 | >30 (4) | 1.69 (−4.61, 8.00), 0.60, 99, <0.00001 |
| ≤ 30 (4) | 3.16 (1.00, 5.32), 0.004, 95, <0.00001 | ≤ 30 (4) | 0.50 (0.16, 0.85), 0.004, 33, 0.21 |
| Total number of participants | Total number of participants | ||
| >100 (2) | 2.06 (−0.19, 4.31), 0.07, 89, 0.003 | >100 (2) | 0.31 (−0.09, 0.70), 0.13, 0, 0.79 |
| ≤ 100 (13) | 0.93 (0.47, 1.39), <0.0001, 97, <0.00001 | ≤ 100 (6) | 1.41 (−2.29, 5.11), 0.45, 99, <0.00001 |
| Mean AHI of OSAS patients, events/h | Mean AHI of OSAS patients, events/h | ||
| >30 (6) | 0.23 (−0.11, 0.57), 0.18, 77, 0.0006 | >30 (4) | 1.38 (0.96, 1.79), <0.00001, 0, 0.53 |
| ≤ 30 (5) | 0.89 (−0.28, 2.05), 0.14, 62, 0.03 | ≤ 30 (3) | 0.38 (0.05, 0.71), 0.02, 0, 0.78 |
BMI, body mass index; CI, confidence interval; OSAS, obstructive sleep apnea syndrome; MD, mean difference; Ph, Pheterogeneity.
Bold numbers show statistically significant value (P < 0.05).