TABLE 3.
Correlation analysis between BTLA and relate genes and markers of immune cells in CRC.
| Description | Gene markers | Pearson r | p | Number of Pairs |
| B cell | CD19 | 0.82 | **** | 610 |
| CD79A | 0.76 | **** | 610 | |
| T cell (general) | CD3E | 0.78 | **** | 610 |
| CD3G | 0.68 | **** | 610 | |
| CD28 | 0.81 | **** | 610 | |
| CD2 | 0.63 | **** | 610 | |
| CD8 + T cell | CD8A | 0.52 | **** | 610 |
| CD8B | 0.28 | **** | 610 | |
| Helper T cell | CD4 | 0.56 | **** | 610 |
| CD40LG (CD40L) | 0.65 | **** | 610 | |
| CXCR4 | 0.49 | **** | 610 | |
| Th1 | T-bet (TBX21) | 0.56 | **** | 610 |
| STAT1 | 0.29 | **** | 610 | |
| STAT4 | 0.68 | **** | 610 | |
| IFN-γ (IFNG) | 0.29 | **** | 610 | |
| TNF-α (TNF) | 0.22 | **** | 610 | |
| Th2 | GATA3 | 0.47 | **** | 610 |
| STAT6 | 0.00 | ns | 610 | |
| STAT5A | 0.33 | **** | 610 | |
| IL13 | 0.13 | * | 379 | |
| Th17 | STAT3 | 0.26 | **** | 610 |
| IL17A | −0.02 | ns | 379 | |
| Tfh | BCL6 | 0.35 | **** | 610 |
| IL21 | 0.65 | **** | 379 | |
| Treg | FOXP3 | 0.41 | **** | 610 |
| CCR8 | 0.39 | **** | 610 | |
| STAT5B | 0.22 | **** | 610 | |
| TGFβ (TGFB1) | 0.28 | **** | 610 | |
| IL2RA (CD25) | 0.47 | **** | 610 | |
| Natural killer cell | FCGR3A (CD16a) | 0.35 | **** | 610 |
| NCAM1 (CD56) | 0.30 | **** | 610 | |
| KIR2DL1 | 0.14 | ** | 379 | |
| KIR2DL3 | 0.15 | *** | 610 | |
| KIR2DL4 | 0.26 | **** | 610 | |
| KIR3DL1 | 0.12 | ** | 610 | |
| KIR3DL2 | 0.21 | **** | 610 | |
| KIR3DL3 | 0.07 | ns | 379 | |
| KIR2DS4 | 0.15 | *** | 610 | |
| Monocyte | CD86 (B7-2) | 0.39 | **** | 610 |
| CD115 (CSF1R) | 0.40 | **** | 610 | |
| TAM | CCL2 | 0.29 | **** | 610 |
| CD68 | 0.23 | **** | 610 | |
| IL10 | 0.33 | **** | 610 | |
| M1 Macrophage | NOS2 | 0.02 | ns | 610 |
| IRF5 | 0.10 | * | 610 | |
| PTGS2 | 0.01 | ns | 610 | |
| M2 Macrophage | CD163 | 0.33 | **** | 610 |
| VSIG4 | 0.32 | **** | 610 | |
| MS4A4A | 0.41 | **** | 610 | |
| Dendritic cell | HLA-DPA1 | 0.42 | **** | 610 |
| HLA-DPB1 | 0.47 | **** | 610 | |
| HLA-DQB1 | 0.34 | **** | 610 | |
| HLA-DRA | 0.38 | **** | 610 | |
| BDCA-1 (CD1C) | 0.58 | **** | 610 | |
| BDCA-4 (NRP1) | 0.36 | **** | 610 | |
| CD11c (ITGAX) | 0.36 | **** | 610 | |
| Neutrophils | CD66b (CEACAM8) | −0.05 | ns | 610 |
| CD11b (ITGAM) | 0.37 | **** | 610 | |
| CCR7 | 0.85 | **** | 610 |
CRC, colorectal cancer; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; TAM, tumor-associated macrophage; ns, p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.