Figure 8.
Effect of RDV on erg-mediated K+ current (I K(erg)) enriched in GH3 cells. The experiments were undertaken in cells bathed in high-K+, Ca2+-free solution, and we filled the electrode using K+-containing solution. (A) Superimposed I K(erg) traces elicited by a series of voltage pulse as indicated in the uppermost part of (A). The traces in the upper part are controls (i.e., RDV was not present), and those in the lower part was obtained 2 min after application of 30 μM RDV. (B) Averaged I-V relationships of I K(erg) obtained in the absence (■) and presence (□) of 30 μM RDV (mean ± SEM; n=9 for each point). Current amplitude was obtained at the beginning of each hyperpolarizing command pulse.