TABLE 2.
Significantly changed genes and KEGG pathways involved in metabolism response in the hepatopancreas of Chinese mitten crab under pH 6.5 vs in the control group for 8 weeks.
Pathway term | Involved genes | P-value |
Oxidative phosphorylation | CYC1, CYT1, petC| SDHA, SDH1| NDUFA12| COX5B| ATPeV1H| NDUFS7ATPF1D, atpH| ATPeF1B, ATP5B, ATP2| QCR2, UQCRC2| ATPeV1F, ATP6S14| UQCRFS1, RIP1, petA| QCR8, UQCRQ| SDHC, SDH3| ATPeF0B, ATP5F1, ATP4| NDUFA4| NDUFAB1| COX5A| NDUFS3| ATPeF0O, ATP5O, ATP5| ATPF0C, atpE| NDUFB2| ATPF1B, atpD| ATPeF1D, ATP5D, ATP16| ppa| NDUFB7 | 3.30E-06 |
Glycolysis/gluconeogenesis | frmA, ADH5, adhC| PDHX| LDH, ldh| E4.1.1.32, pckA, PEPCK| PGK, pgk | ENO, eno| DLAT, aceF, pdhC| PTS-Glc-EIIA, crr| GPI, pgi| ACSS, acs| PDHA, pdhA| GAPDH, gapA| DLD, lpd, pdhD| FBA, fbaA | 6.07 E-04 |
Citrate cycle (TCA cycle) | PDHX| IDH1, IDH2, icd| E4.1.1.32, pckA, PEPCK| SDHC, SDH3| | DLAT, aceF, pdhC | MDH2| SDHA, SDH1| PDHA, pdhA| ACO, acnA| DLD, lpd, pdhD | 8.39 E-04 |
Pyruvate metabolism | PDHX| LDH, ldh| E4.1.1.32, pckA, PEPCK| MDH2| DLAT, aceF, pdhC| ACSS, acs| PDHA, pdhA| DLD, lpd, pdhD | 0.011 |
Starch and sucrose metabolism | UGT| UGDH, ugd| E3.2.1.28, treA, treF| E3.2.1.4| MGAM| SI| PTS-Glc-EIIA, crr| UGP2, galU, galF| GPI, pgi| TPS | 0.011 |
Taurine and hypotaurine metabolism | CSAD| GADL1, CSADC, ADC | 0.034 |
Glutathione metabolism | IDH1, IDH2, icd| GST, gst | E1.11.1.9| GCLC| E4.1.1.17, ODC1, speC, speF | 0.042 |
Amino sugar and nucleotide sugar metabolism | E3.2.1.14| PTS-Nag-EIIC, nagE| HEXA_B| PTS-Glc-EIIA, crr| UGP2, galU, galF| GPI, pgi | 0.045 |
Steroid biosynthesis | E1.14.13.72, SC4MOL, ERG25| DHCR24 | 0.046 |
Pentose and glucuronate interconversions | UGT| UGDH, ugd | DHDH| UGP2, galU, galF| DCXR | 0.050 |