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The ACER2/SMPDL3B axis promotes ceramides hydrolysis and S1P production. Huh‐7 cells with stable ACER2 knockdown (A, B) or overexpression (C, D) were transfected with the SMPDL3B expression vector (A, B) or SMPDL3B siRNA (C, D) for 48 h. Intracellular ceramides (A, C) and S1P (B, D) were measured. Error bars represent the SD from 3 independent experiments, and statistical significance was analyzed using Student t test. *, #P < .05; **P < .01; ***P < .001
