Table 2.
Sphingolipid signaling genes changes after ACER2 downregulation
| Gene | CT in cells with control shRNA | CT in cells with ACER2 shRNA | Fold of control |
|---|---|---|---|
| ACER2 | 28.11 | 29.75 | −3.3 |
| SMPDL3B | 28.24 | 30.94 | −5 |
| FAAH | 32.75 | 34.12 | −2.5 |
| GBA3 | 32.54 | 33.69 | −2 |
| SMPDL3A | 25.94 | 26.96 | −2 |
| FAAH2 | 25.89 | 26.94 | −2 |
| SGMS1 | 22.86 | 23.70 | −1.7 |
| SMPD1 | 24.82 | 24.11 | 1.6 |
| SGPP2 | 31.98 | 31.32 | 1.6 |
| SPHK1 | 23.90 | 23.49 | 1.3 |
The value in bold indicated the largest fold of change. Abbreviations: ACER2, alkaline ceramidase 2; FAAH, fatty‐acid amide hydrolase; FAAH2, fatty‐acid amide hydrolase 2; GBA3, glucocerebrosidase 3; SGMS1, phosphatidylcholine ceramide choline phosphotransferase 1; SGPP2, sphingosine‐1‐phosphate phosphatase 2; SMPD1, sphingomyelin phosphodiesterase 1; SMPDL3A, acid sphingomyelinase‐like phosphodiesterase 3a; SMPDL3B, acid sphingomyelinase‐like phosphodiesterase 3b; SPHK1, sphingosine kinase 1.