Figure 5.

Knockdown (KD) of PSF1 induces cell death in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) cells. Cell death analysis (red box: apoptosis and necrosis) of PSF1 KD THP‐1 (A, B) and MEG‐1 (E, F) cells. Proportions of dead cells in PSF1‐KD THP‐1 (B) and MEG‐1 (F) cells were calculated and compared with the Ctrl group (n = 4). Error bars represent means ± SD; ***P < .001. Analysis of cell death in PSF1 KD THP‐1 (C, D) and MEG‐1 (G, H) cells following AraC treatment (2 and 4 μmol/L). Quantification of cell death of PSF1‐KD THP‐1 (D) and MEG‐1 (H) cells compared with the Ctrl group (n = 4). Error bars represent means ± SD; *P < .05; ***P < .001