TABLE 3.

A simple linear regression analysis of 14 metabolites with elevated concentrations in the ccRCC group

Metabolite	Mean [µmol/L/u‐Cre (mmol/L)]	SD	AUC	Sensitivity (%)	Specificity (%)	Cut off [µmol/L/u‐Cre (mmol/L)]
d‐Sedoheptulose 7‐phosphate	30.579	53.05	0.848	74.71	81.7	2.2454
Lactate	75.868	216.23	0.781	77.01	75.0	27.991
Myoinositol	23.728	35.04	0.780	66.7	81.7	8.78
l‐Kynurenine	0.100	0.09	0.740	64.4	80.0	0.056
Picolinic acid	0.034	0.03	0.720	85.1	53.3	0.011
Succinic acid	0.148	0.22	0.715	52.9	83.3	0.10
2‐Hydroxyglutarate	357.708	282.56	0.690	46.0	95.0	324.08
Nicotinic acid	0.005	0.005	0.680	88.5	45.0	0.001
GSH	0.829	1.42	0.680	85.06	51.6	0.122
l‐Tryptophan	0.618	0.75	0.660	51.7	80.0	0.472
Phosphorylcholine	0.509	0.45	0.650	75.9	50.0	0.23
α‐d‐Glucose 1‐phosphate	0.423	0.66	0.640	57.5	44.4	0.17
d‐Fructose 6‐phosphate	0.402	0.59	0.638	64.4	61.7	0.16
l‐Glutamine	1268.288	2287.6	0.454	40.2	93.3	1076.49

Abbreviations: ccRCC, clear cell renal cell carcinoma; GSH, glutathione reduced form; u‐Cre, urinary creatinine.