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. 2020 May 29;111(7):2325–2335. doi: 10.1111/cas.14484

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The 8‐gene signature‐related immune responses and inflammatory activities in gliomas in the CGGA dataset. A‐C, Correlation of immune checkpoint members and risk signature in whole gliomas, low‐grade gliomas (LGG), and glioblastoma multiforme (GBM), respectively. D, The relationship between the risk signature and T‐cell‐related immunity. GO:0042088: T‐helper 1 type immune response; GO:0042092: T‐helper 2 type immune response; GO:2000556: positive regulation of T‐helper 1 cell cytokine production; GO:2000553: positive regulation of T‐helper 2 cell cytokine production; GO:0002860: positive regulation of natural killer cell‐mediated cytotoxicity directed against tumor cell target; GO:0002842: positive regulation of T cell‐mediated immune response to tumor cell; GO:0002852: regulation of T cell‐mediated cytotoxicity directed against tumor cell target. E, Relationship between CMTM6 and inflammatory activities. *** P < .001, **** P < .0001, ns: not statistically significant