FIGURE 1.

Immunohistochemical staining of SLC12A5 in BUC tissues and its prognostic significance in patients with BUC. A, BUC case (case 6) exhibiting low expression of SLC12A5, in which less than 20% of carcinoma cells showed positive staining for SLC12A5. B‐D, High expression of SLC12A5 was observed in other BUC (cases 21, 45, 78), in which more than 80% of carcinoma cells demonstrated positive staining for SLC12A5. E, F High expression of SLC12A5 was associated with poor prognosis of patients with BUC. Kaplan‐Meier plots show the overall survival curves of 112 patients with BUC in the learning cohort (E) and 126 patients with BUC in the validation cohort (F), according to SLC12A5 expression levels in the primary tumor (P < .05, log‐rank test)