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. 2020 May 20;111(7):2598–2607. doi: 10.1111/cas.14435

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Latent membrane protein 2A (LMP2A) plays an important role in maintenance of cancer stem cells in Epstein‐Barr virus (EBV)‐associated gastric cancer. A and B, Relative mRNA expression of LMP2A in monolayer cells (2D) and sphere‐forming cells (spheroid) of SNU719 and EBV⁺ TMK1 cells, respectively. C and D, Effects of LMP2A knockdown on spheroid formation of SNU719 cells, respectively. A total of 10 000 cells were seeded in each well. Measurement of the number (C) and diameter (D) of spheroid colonies after 7 days. E and F, Effects of LMP2A transfection on spheroid formation of TMK1 cells. A total of 500 cells were seeded in each well. Measurement of the number (E) and diameter (F) of spheroid colonies after 7 days (left). All data are shown as mean ± SD; **P < .01, Mann‐Whitney U test