FIGURE 2.

Integrin β8 (ITGB8) regulates tumor progression through Y‐box binding protein 1 (YBX1). A, Expression of phosphorylated (p‐)YBX1 and total (t‐)YBX1 in Biu87 and Biu87/ITGB8 cells. B, C, Relative proliferation (B) and relative colony formation (C) of Biu87/ITGB and YBX1 silenced Biu87/ITGB8 cells. D, E, Cytotoxicity of Biu87/ITGB8 and YBX1 silenced Biu87/ITGB8 cells treated with mitomycin C (0.5 μg/mL, 24 h) (D) or hydroxycamptothecin (0.5 μg/mL, 24 h) (E). F, Expression of p‐YBX1 and t‐YBX1 in low malignant (LM; stage T0, Ta, Tis) and high malignant (HM; stage T3, T4) tumor tissues from bladder cancer patients. *P < .05; **P < .01