FIGURE 4.

Gelsolin (GSN) knockdown resulted in enhanced viability of glioblastoma (GBM) cells in vivo. A, U87 cells transfected with shGSN showed downregulated GSN expression by western blot analysis. B, Weight of mice (n = 10) was measured for 26 d to make weight curve lines. ***P < .001, 2‐way ANOVA. C, D, Slide sections of mouse brain were stained with H&E, and the size of tumor on the slide section was tested individually by ImageJ software. Magnification, 20×. *P < .05, Student’s t test. Expression was investigated by immunofluorescence: GSN, green; DAPI, blue. Magnification, 400×. NC, negative control