FIGURE 6.

MicroRNA (miR)‐654‐5p and miR‐450b‐5p inhibitors reduced cell viability through gelsolin (GSN) in glioblastoma (GBM) cell lines. A, Expression of miR‐654‐5p and miR‐450b‐5p in GBM cell lines was detected by quantitative real‐time (qRT)‐PCR. B, After treatment with miR‐654‐5p and miR‐450b‐5p inhibitors, GSN expression was enhanced, as determined using qRT‐PCR. *P < .05, Student’s t test. C, Cell invasion ability influenced by miR inhibitors were measured using invasion chambers, and cell numbers were calculated. *P < .05; ***P < .001, 1‐way ANOVA. D, Proliferation was measured in cells treated with 20 nmol/L miRNA inhibitors. **P < .01; ***P < .001, 2‐way ANOVA. OD, optical density. E, Function of GSN and its related molecules in GBM. GSK, glycogen synthase kinase; NC, negative control