Table 2.
Inverse probability weighted mean difference (95% CI) in amyloid-β deposition, hippocampal volume, and white matter lesion volume in 2009 according to usual alcohol consumption in 2000 to 2002 in 189 participants of the GEM imaging study
| Mean difference (95% CI) by weekly number of drinks | Continuous per drink | p for linear trend (quadratic)a | |||||
|---|---|---|---|---|---|---|---|
| Non-drinker | 0.1–0.9 | 1.0–7.0 | 7.1–14.0 | >14 | |||
| Amyloid-β deposition, SUVR, n = 189 | |||||||
| Basic modelb | 0.06 (−0.22, 0.34) | 0 | −0.07 (−0.35, 0.22) | 0.18 (−0.15, 0.52) | −0.15 (−0.54, 0.24) | −0.005 (−0.021, 0.012) | 0.58 (0.10) |
| Full modelc | 0.07 (−0.20, 0.34) | 0 | −0.13 (−0.40, 0.14) | 0.03 (−0.28, 0.34) | −0.24 (−0.61, 0.12) | −0.013 (−0.027, 0.002) | 0.09 (0.40) |
| White matter lesion volume, % ICV × 100, n = 169 | |||||||
| Basic modelb | 0.29 (0.03, 0.55) | 0 | 0.20 (−0.11, 0.50) | 0.29 (−0.04, 0.62) | 0.30 (−0.14, 0.74) | 0.01 (−0.01, 0.03) | 0.37 (0.49) |
| Full modelc | 0.25 (0.01, 0.50) | 0 | 0.20 (−0.10, 0.50) | 0.32 (−0.03, 0.67) | 0.31 (0.01, 0.62) | 0.015 (−0.004, 0.034) | 0.13 (0.27) |
| Hippocampal volume, %ICV × 100, n = 169 | |||||||
| Basic modelb | −0.70 (−2.10, 0.70) | 0 | 0.46 (−1.08, 2.01) | −1.44 (−3.81, 0.93) | −0.68 (−2.26, 0.90) | −0.07 (−0.19, 0.06) | 0.32 (0.90) |
| Full modelc | −0.57 (−2.06, 0.92) | 0 | 0.58 (−1.15, 2.31) | −0.80 (−3.39, 1.78) | −0.24 (−2.20, 1.73) | −0.03 (−0.15, 0.10) | 0.38 (0.96) |
ICV, intracranial volume. SUVR, standardized uptake value ratio.
All values > 97.5 percentile set to the 97.5th percentile.
Adjusted for sex, age, and race/ethnicity.
Additionally adjusted for education, social activity, frequency of walking for exercise or pleasure, smoking status, body mass index, lipid-lowering medication use, history of cardiovascular disease, systolic blood pressure, antihypertensive medication use, history of diabetes, Center for Epidemiologic Studies-Depression Scale, and treatment arm assignment.