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. 2020 Jul 21;14:765. doi: 10.3389/fnins.2020.00765

FIGURE 2.

FIGURE 2

The activity of U50,488, 16-Ethynyl SalA, and 16-Bromo SalA in the cyclic adenosine monophosphate (cAMP) and β-arrestin recruitment assays. (A) The KOPr agonists were measured for inhibition of forskolin-induced cAMP (HitHunterTM): U50,488 n = 29 across 11 experiments, 16-Ethynyl SalA n = 36 across 16 experiments, 16-Bromo SalA n = 18 across six experiments and (B) β-arrestin recruitment (PathHunterTM): U50,488 n = 26 across nine experiments, 16-Ethynyl SalA n = 12 across three experiments, 16-Bromo SalA n = 15 across five experiments. Values presented as mean ± SEM.