Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 21;14:765. doi: 10.3389/fnins.2020.00765

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Paton, Biggerstaff, Kaska, Crowley, La Flamme, Prisinzano and Kivell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

KOPr agonists cause motor incoordination in the rotarod performance assay. Using a rotarod apparatus set to accelerate from 4 to 40 rpm over 300 s, SalA showed a significant effect at 15–30 min. (A) 16-Ethynyl showed a significant effect at 15–30 min. (B) 16-Bromo SalA had a significant impairment at 15–30 min at 1 mg/kg. Two-way repeated-measures ANOVA, **p < 0.01, ****p < 0.0001 for 2 mg/kg dose (above) or SalA (below) vs. vehicle. ^#p < 0.05, ^###p < 0.001 for 1 mg/kg dose vs. vehicle. ^∧indicates time point where SalA is more sedative than both doses of the novel analog. Values presented as mean ± SEM, n = 6.