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. 2020 Jul 21;14:223. doi: 10.3389/fncel.2020.00223

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Copyright © 2020 Zhang, Jin, Wang, Liu, Zhang, Zheng, Lin, Yang, He, Lin, Chen and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electro-acupuncture promotes the differentiation of endogenous neural stem cells into neurons in peri-ischemic striatum and SVZ of ischemic hemisphere. (A) Immunofluorescence and co-localization of NeuN with BrdU in peri-ischemic striatum (B). Immunofluorescence and co-localization of NeuN with BrdU in the subventricular zone (SVZ) of ischemic hemisphere. (C,D) The positive cells of co-localization of NeuN/Brdu in peri-ischemic striatum and SVZ of ischemic hemisphere, respectively (n = 4). Data represent means ± SD of the results of representative experiment. ^&P< 0.05 and ^&&P< 0.01, MCAO vs. MCAO+miR-146b inhibitors; ^##P< 0.01, MCAO vs. MCAO+EA; ^$$P< 0.05, MCAO+miR-146b inhibitors vs. MCAO+EA+miR-146b inhibitors.