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Pharmacokinetics of novobiocin and coumermycin. Female BALB/c mice (n = 3 per group) were intraperitoneally administered (A) 15 mg/kg coumermycin or (B) 15 mg/kg novobiocin with or without formulation in an equimolar concentration of dl-tryptophan (dose volume 10 mL/kg). Error bars represent the standard deviation from the mean. Plasma concentrations of the compound were assessed by mass spectrometry at different time points as indicated.
