Skip to main content
. 2020 Jul;56(1):106002. doi: 10.1016/j.ijantimicag.2020.106002

Table 1.

Summary of mean pharmacokinetic parameters.

Parameter Coumermycin
 Novobiocin
Alone + dl-tryptophan Alone + dl-tryptophan
t1/2 (h) 6 6 3 3
Tmax (h) 2 2 1 1
Cmax (nM) 102 767 103 297 10 739 10 739
AUClast (h•nM) 957 128 909 773 33 198 33 198
AUCall (h•nM) 957 128 909 773 33 198 33 198
AUCinf (h•nM) 1 016 517 963 025 33 240 33 240

t1/2, elimination half-life; Tmax, time to maximum concentration; Cmax, maximum concentration; AUC, area under the concentration–time curve (AUClast, AUC from 0 h to last measurable concentration; AUCall, AUC for all values; AUCinf, AUC from 0 h to infinity).