Table 3.
The ranks of real virus receptors among the RBP-interacting human cell membrane proteins by likelihood ratio (LR) and random-forest (RF) score.
| Virus name | RBP | Real viral receptor | Num of RBP-interacting proteins | Rank by LR | Rank by RF score |
|---|---|---|---|---|---|
| SARS-CoV | S | ACE2 | 31 | –* | 22 |
| MERS-CoV | S | DPP4 | 8 | – | 2 |
| Echovirus E6 | VP1 | CD55 | 13 | 5 | 2 |
| Echovirus E11 | VP1 | CD55 | 9 | 4 | 2 |
| Echovirus E7 | VP1 | CD55 | 7 | – | 3 |
| Echovirus E13 | VP1 | CD55 | 11 | 4 | 1 |
| Echovirus E20 | VP1 | CD55 | 12 | 5 | 1 |
| Echovirus E29 | VP1 | CD55 | 13 | 6 | 2 |
| Echovirus E33 | VP1 | CD55 | 13 | 6 | 1 |
| Enterovirus C | VP1 | PVR | 5 | – | 1 |
| Hepacivirus C | E1 | EGFR | 17 | 10 | 2 |
| MACV | GPC | TFRC | 2 | – | 1 |
| Measles virus | H | NECTIN4 | 18 | – | 18 |
| Measles virus | H | SLAMF1 | 18 | 2 | 2 |
| Hendra virus | G | EFNB2 | 5 | – | 1 |
| Nipah virus | G | EFNB2 | 5 | – | 1 |
| HAdV-A | L5 | CXADR | 25 | – | 16 |
| HAdV-C | L5 | CXADR | 5 | 4 | 5 |
| HAdV-D | L5 | CXADR | 28 | 4 | 15 |
| HAdV-E | L5 | CXADR | 33 | 3 | 24 |
| HSV-1 | US6 | TNFRSF14 | 28 | – | 3 |
| HSV-1 | US6 | NECTIN1 | 28 | – | 11 |
| HSV-2 | US6 | NECTIN1 | 34 | – | 14 |
| HSV-2 | US6 | TNFRSF14 | 34 | 23 | 3 |
| HIV-1 | env | CD4 | 21 | – | 1 |
| Top 1 | 0 | 8 (3)# | |||
| Top 3 | 2 | 17 (9)# | |||
| Top 5 | 8 | 18 (10)# | |||
| Median rank percentage | 0.43 | 0.20 (0.14)# | |||
The median rank percentage of real virus receptors among RBP-interacting human cell membrane proteins, and the number of real virus receptors among top one, three and five ranks were summarized at the bottom.
MACV machupo mammarenavirus, HAdV-A human mastadenovirus A, HAdV-C human mastadenovirus C, HAdV-E human mastadenovirus E, HAdV-D human mastadenovirus D, HSV-1 human alphaherpesvirus 1, HSV-2 human alphaherpesvirus 2, HIV-1 human immunodeficiency virus 1.
*No LR was provided in Lasso’s work since there were resolved complex structures between the RBP and the receptor.
#The number in brackets referred to those when only considering 12 pairs of viral RBP-receptor interaction with LRs available from Lasso’s work.