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. 2020 Jul 27;11(7):593. doi: 10.1038/s41419-020-2726-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b, d The expression levels of both HMGA2 mRNA and protein were upregulated in the circASPH-overexpressing A549 and PC9 cells. c The predicted target site of miR-370 on HMGA2 mRNA 3′-UTR and the schematic diagram of site-directed mutations of the predicted target site. e Dual-luciferase reporter assay analysis of the effect of miR-370 on the 3′-UTR activity of HMGA2 in 293T cells. f Dual-luciferase reporter assay analysis of the effect of miR-370 on the 3′-UTR activity of HMGA2 in the circASPH-overexpressing and control 293T cells. g–i The expression levels of both HMGA2 mRNA and protein were significantly decreased in the miR-370-overexpressing A549 and PC9 cells. Every cell test was carried out in triplicate, and n = 3 for each cell group.