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. 2020 Jul 27;11:3739. doi: 10.1038/s41467-020-17372-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative images of testis sections from adult Tex15^+/− and Tex15^−/− mice stained with PAS and Haematoxylin (n = 3). Scale bar 50 µm. b, c Representative images of testis sections of (n = 3) adult Tex15^+/− and Tex15^−/− mice stained for (b) γH2AX showing DNA damage response or (c) TUNEL visualising apoptotic cells. DNA stained with DAPI. Scale bar 50 µm. d, e Adult Tex15^+/− and Tex15^−/− testis sections (n = 3) stained for (d) LINE1 ORF1p or (e) IAP-GAG protein. DNA stained with DAPI. Scale bar 50 µm. f Heat map from P20 testes and E16.5 gonocytes RNA-seq as indicated showing fold change of the ten most upregulated LINEs and ERVKs in Tex15^−/− and Miwi2^−/− P20 testis compared to control (n = 3). P < 0.01, Benjamini–Hochberg adjusted two-sided Wald test.