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. 2020 Jul 27;11:3739. doi: 10.1038/s41467-020-17372-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b piRNAs analysis of Tex15^+/− and Tex15^−/− from small RNA sequenced E16.5 testes (n = 3). a Length distribution of small RNAs, data shows mean and s.e.m. P = 1, two sample t-test, Bonferroni adjustment. b piRNA annotation. c Representative images of MIWI2 stained E16.5 testis sections from Tex15^+/− and Tex15^−/− mice (n = 3). Scale bar 10 µm. d–g Genomic CpG methylation analysis from Wildtype, Tex15^−/− and Miwi2^−/− (n = 3) P14 undifferentiated spermatogonia. d CpG methylation percentage of TEs (non-overlapping genes). Box range indicates 25th to 75th percentile (interquantile range), line the median, whiskers range of median ± 2 interquantile range, dots datapoints outside this range. e Metaplots showing mean CpG methylation over LINE1 elements and adjacent 2 kb. f CpG methylation loss in Tex15^−/− relative to Wildtype plotted against divergence from consensus sequence. g Mean CpG methylation level of maternal and paternal imprinted regions, Rasgrf1 shown in detail.