Table 3.
Summary of findings.
| Chinese medical drug and western medicine compared to western medicine for coronavirus disease 2019 | |||||
|---|---|---|---|---|---|
| Patient or population: Patients with coronavirus disease 2019 Intervention: CHM + WM Comparison: WM | |||||
| Outcomes | No. of participants (studies) Follow up | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects |
|
| Risk with western medicine | Risk difference with Chinese medical drug and western medicine | ||||
| Number of patients turned to the types of severe and critical | 989 (8 RCTs) | ⨁⨁⨁◯ MODERATE a | RR 0.47 (0.32 to 0.69) | 140 per 1000 | 74 fewer per 1000 (95 fewer to 43 fewer) |
| Length of hospital stay | 12 (1 RCT) | ⨁⨁◯◯ LOW a,b | – | – | MD 7.95 lower (14.66 lower to 1.24 lower) |
| Defervescence time | 250 (2 RCTs) | ⨁⨁⨁◯ MODERATE a,c | – | – | MD 1.2 lower (2.03 lower to 0.38 lower) |
| Cough resolution rate | 264 (3 RCTs) | ⨁⨁◯◯ LOW a,b | RR 1.37 (1.15–1.64) | 523 per 1000 | 194 more per 1000 (79 more to 335 more) |
| Fatigue resolution rate | 147 (2 RCTs) | ⨁⨁◯◯ LOW a,b | RR 1.37 (1.02–1.83) | 431 per 1000 | 160 more per 1000 (9 more to 358 more) |
| Tachypnea resolution rate | 35 (1 RCT) | ⨁⨁◯◯ LOW a,b | RR 2.20 (1.11–4.39) | 353 per 1000 | 424 more per 1000 (39 more to 1196 more) |
GRADE Working Group grades of evidence: High certainty: We are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; MD: Mean difference a. Unclear risk of bias b. Small sample size c. High heterogeneity.