Table 1.

Characteristics of the included studies.

Author	Year	Country	microRNAs	Regulation mode	Sample size		Speci-men	Diagnostic power
					OS patients	Healthy		Sen (%)	Spe (%)	AUC
Single microRNA
Zhu [29]	2017	China	miR-17-5p	Upregulated	62	36	Plasma	0.500	0.972	0.793
Fujiwara [30]	2017	Japan	miR-17-5p	Upregulated	14	22	Serum	0.643	0.846	0.720
Fujiwara [30]	2017	Japan	miR-25-3p	Upregulated	14	22	Serum	0.714	0.923	0.868
Tang [31]	2015	China	miR-27a	Upregulated	166	60	Serum	0.700	0.983	0.867
Zhang [32]	2017	China	miR-27b	Upregulated	51	51	Serum	0.778	0.867	0.863
Zhi [33]	2016	China	miR-34a	Downregulated	50	50	Serum	0.867	0.686	0.830
Wang [34]	2017	China	miR-34a	Downregulated	120	87	Serum	0.680	0.920	0.830
Yao [35]	2018	China	miR-101	Downregulated	152	70	Serum	0.790	0.829	0.850
Cong [36]	2018	China	miR-124	Downregulated	114	50	Serum	0.798	0.860	0.846
Xiao [37]	2016	China	miR-125b	Downregulated	20	20	Serum	0.900	0.950
Zhou [25]	2018	China	miR-139-5p	Downregulated	98	50	Serum	0.765	0.800	0.846
Zhang [38]	2020	China	miR-144	Downregulated	51	48	Serum	0.738	0.882	0.852
Ma [39]	2014	China	miR-148a	Downregulated	89	89	Plasma	0.697	0.831	0.783
Wang [40]	2015	China	miR-152	Downregulated	80	20	Serum	0.925	0.962	0.956
Wang [41]	2015	China	miR-191	Upregulated	100	20	Serum	0.740	1	0.858
Shi [42]	2020	China	miR-194	Downregulated	124	60	Serum	0.842	0.791	0.855
Cai [43]	2015	China	miR-195	Downregulated	166	60	Serum	0.880	0.833	0.892
Zhou [44]	2015	China	miR-199a-5p	Upregulated	60	60	Serum	0.883	0.767	0.861
Yang [45]	2015	China	miR-211	Upregulated	108	50	Serum	0.657	1	0.844
Zhang [46]	2016	China	miR-222	Downregulated	57	57	Serum	0.667	0.842	0.811
Dong [47]	2016	China	miR-223	Downregulated	122	50	Serum	0.895	0.972	0.926
Liu [48]	2019	China	miR-223	Downregulated	53	30	Serum	0.736	0.600	0.747
Zhang [49]	2019	China	miR-223	Downregulated	38	38	Serum	0.763	0.947	0.900
Liu [50]	2016	China	miR-300	Upregulated	114	114	Serum	0.842	0.886	0.885
Cao [51]	2016	China	miR-326	Downregulated	60	20	Serum	0.837	0.945	0.897
Liu [27]	2018	China	miR-375	Downregulated	95	95	Serum	0.840	0.844	0.830
Wang [52]	2017	China	miR-491-5p	Downregulated	72	40	Serum	0.720	0.860	0.834
Li [53]	2018	China	miR-542-3p	Upregulated	76	76	Serum	0.778	0.936	0.841
Liu [48]	2019	China	miR-586	Upregulated	53	30	Serum	0.642	0.700	0.743
Huang [26]	2019	China	miR-663a	Upregulated	50	50	Plasma	0.674	0.898	0.860
microRNA clusters
Ouyang [54]	2013	China	miRNA clusters (miR-21, miR-199a-3p, miR-143)	Downregulated	40	40	Plasma	0.905	0.938	0.953
Ren [55]	2014	china	miRNA clusters (miR-199b-5p/miR-124)	Upregulated	22	30	Plasma	0.960	0.970	0.993
Lian [56]	2015	China	miRNA clusters (miR-195-5p, miR-199a-3p, miR-320a, miR-374a-5p)	Upregulated	90	90	Plasma	0.911	0.944	0.961
Liu [48]	2019	China	miRNA clusters (miR-586, miR-223)	Upregulated	53	30	Serum	0.887	0.634	0.813